Preferred Label : iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576;
NCIt synonyms : CD16/IL-15RF-expressing CD38-eliminated Anti-BCMA CAR-iNK Cells FT576; iPSC-derived Anti-BCMA CAR-CD16-IL-15RF-expressing CD38-eliminated NKs FT576; iPSC-derived CD16/IL-15RF-expressing CD38-eliminated Anti-BCMA CAR-NK Cells FT576; iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated Natural Killer
Cells FT576;
NCIt definition : An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal
master induced pluripotent stem cell (iPSC) line, and engineered and multiplex-edited
to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen
(TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily
member 17; TNFRSF17), a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and
a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate
CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon
administration, iPSC-derived anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated
NK cells FT576 recognize, bind to and induce selective cytotoxicity in BCMA-expressing
tumor cells, leading to tumor cell lysis and the release of tumor neoantigens. Additionally,
FT576 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell
activity and recruitment to the tumor site. BCMA, a receptor for both a proliferation-inducing
ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis
factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells,
is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation
and survival. IL-15RF promotes the survival of NK cells and enhances the cytotoxic
effect of the NK cells and the activated anti-tumor T-cells. When used in combination
with monoclonal antibodies, the hnCD16 Fc receptor of FT576 binds to the Fc portion
of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine
secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also
known as Fc-gamma receptor III, is normally expressed on the surface of NK cells,
neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It
is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune
response. The lack of CD38 in FT576 NK cells prevents NK cell fratricide upon co-administration
with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface
of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies.;
Molecule name : FT-576; FT 576;
NCI Metathesaurus CUI : CL1778969;
Origin ID : C186430;
UMLS CUI : C5667062;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
