NCIt definition : A bispecific antibody directed against both a mutant form of the human epidermal growth
factor receptor (EGFR), EGFR variant III (EGFRvIII), and the T-cell surface antigen
CD3, with potential immunostimulating and antineoplastic activities. Upon administration,
anti-EGFRvIII/CD3 bispecific antibody RO7428731 specifically binds to both CD3 on
cytotoxic T-lymphocytes (CTLs) and EGFRvIII on EGFRvIII-expressing tumor cells. This
crosslinks T-cells and tumor cells, and activates and redirects CTLs to EGFRvIII-expressing
tumor cells. This leads to CTL-mediated killing of EGFRvIII-expressing tumor cells.
EGFRvIII, a mutant form of EGFR expressed in certain tumor cell types and frequently
seen in malignant glioma, plays a key role in tumor cell proliferation and survival.;
Semantic type(s)