Preferred Label : Oncolytic Adenovirus Expressing Interferon YSCH-01;
NCIt synonyms : Oncolytic Adenovirus Expressing IFN YSCH-01; Oncolytic Adenovirus YSCH-01; Recombinant Oncolytic Adenovirus L-IFN YSCH-01; Oncolytic Virus YSCH-01;
NCIt definition : An oncolytic adenovirus that has been genetically engineered to express interferon
(IFN), with potential immunostimulating and antineoplastic activities. Upon intratumoral
administration, the oncolytic adenovirus expressing IFN YSCH-01 selectively infects
and replicates in tumor cells, leading to tumor cell lysis. In addition, tumor cell
lysis releases a variety of tumor-associated antigens (TAAs), which may potentially
result in the activation of a systemic immune response against the TAAs-expressing
tumor cells. The IFN expressed by the oncolytic adenovirus also activates T-lymphocytes,
dendritic cells (DCs) and natural killer (NK) cells and induces an anti-tumor immune
response against the tumor cells.;
Molecule name : YSCH 01; YSCH-01;
NCI Metathesaurus CUI : CL1778594;
Origin ID : C186376;
UMLS CUI : C5667058;
Semantic type(s)
- concept_is_in_subset
