Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters

Preferred Label : Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters;

NCIt synonyms : DGONC;

NCIt definition : A provisional tumor entity described in the supratentorial brain and characterized by a distinct DNA methylation profile and monosomy of chromosome 14. It is composed of small to medium-sized cells showing perinuclear oligodendroglioma-like haloes, scattered multinucleated cells, and nuclear clusters composed of large pleomorphic nuclei. Most cases have been reported in pediatric patients.;

Neoplastic status : Undetermined;

Concept status : Provisional_Concept;

NCI Metathesaurus CUI : CL1778510;

Détails

Origin ID

C185935;

UMLS CUI

C5666829;

Disease excludes normal cell origin
- Oligodendrocyte [NCIt concept]
Excludes anatomical site(s)
- Spinal Cord [NCIt concept]
Has associated anatomic sites
- Brain [NCIt concept]
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
- Supratentorial Brain [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Precise Histogenesis Unknown [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Multinucleated Giant Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Neoplastic Oligodendrocyte-Like Cell [NCIt concept]
disease_has_normal_cell_origin
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
- Supratentorial Brain [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Monosomy 14 [NCIt concept]

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