Preferred Label : Lipid Nanoparticle-encapsulated EBV mRNA Vaccine mRNA-1189;
NCIt synonyms : LNP-encapsulated mRNA-based EBV Vaccine mRNA-1189; Anti-EBV mRNA Vaccine mRNA-1189; LNP-encapsulated EBV mRNA Vaccine mRNA-1189;
NCIt definition : A vaccine consisting of a lipid nanoparticle (LNP) encapsulating four messenger RNAs
(mRNAs) encoding the Epstein-Barr Virus (EBV) envelope glycoproteins gp42, gp220,
gH and gL, with potential immunizing activity against EBV. Upon intramuscular administration
of LNP-encapsulated EBV mRNA vaccine mRNA-1189, the LNP binds to the plasma membrane
of cells and releases the mRNAs into the cells. The mRNAs are then translated by ribosomes
to produce the EBV envelope glycoproteins. This may activate both humoral and cellular
immune responses which may result in protection against EBV infection. EBV, a ubiquitous
human herpes virus, is associated with infectious mononucleosis and various malignancies,
including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other
lymphomas.;
Molecule name : mRNA-1189; mRNA 1189;
NCI Metathesaurus CUI : CL1778250;
Origin ID : C185869;
UMLS CUI : C5667036;
Semantic type(s)
- concept_is_in_subset
