Preferred Label : Fluorine F 18 4-Fluoro-1-naphthol;
NCIt synonyms : [18F]4FN; 4-[18F]fluoro-1-naphthol;
NCIt related terms : 4-FLUORO-1-NAPHTHOL F-18;
NCIt definition : A radioconjugate composed of a myeloperoxidase (MPO) activity tracer labeled with
fluorine F 18, with potential use for imaging of MPO activity and areas of inflammation
using positron emission tomography (PET). Upon administration of fluorine F 18 4-fluoro-1-naphthol,
the 4-fluoro-1-naphthol moiety selectively binds to nearby proteins and cells when
they are oxidized by MPO plus hydrogen peroxide, but not hydrogen peroxide alone.
This allows the visualization of MPO activity using PET. MPO is one of the key effector
molecules and enzymes of innate immunity.;
UNII : 77AYZ3N6WD;
CAS number : 2507735-84-2;
NCI Metathesaurus CUI : CL1778331;
Origin ID : C185735;
UMLS CUI : C5670042;
Semantic type(s)
- concept_is_in_subset
