Preferred Label : SETD2 Inhibitor EZM0414;
NCIt related terms : EZM-0414;
NCIt definition : An orally bioavailable selective inhibitor of the histone methyltransferase (HMT)
SETD2 (SET domain containing 2, histone lysine methyltransferase), with potential
antineoplastic activity. Upon oral administration, SETD2 inhibitor EZM0414 binds to
SETD2 and inhibits its activity. This prevents several key biological processes that
are mediated by SETD2, including the methylation of histones and non-histone proteins,
transcriptional regulation, RNA splicing, DNA damage repair and B cell development
and maturation. The inhibition of SETD2 by EZM0414 may inhibit tumor cell proliferation.
SETD2 plays multiple important roles in oncogenesis.;
UNII : KCY37T9RXU;
Molecule name : EZM-0414; EZM 0414;
NCI Metathesaurus CUI : CL1773734;
Origin ID : C185420;
UMLS CUI : C5666991;
Semantic type(s)
- concept_is_in_subset
- has_target
