" /> Imdatifan - CISMeF





Preferred Label : Imdatifan;

Obsolete resource : true;

NCIt synonyms : HIF2a Inhibitor NKT2152; HIF-2alpha Inhibitor NKT 2152;

NCIt definition : An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor NKT2152 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.;

NCIt note : See 'Imdatifan(C203107)';

Concept status : Retired_Concept;

Molecule name : NKT 2152; NKT-2152;

NCI Metathesaurus CUI : CL1773733;

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30/07/2025


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