Preferred Label : Imdatifan;
Obsolete resource : true;
NCIt synonyms : HIF2a Inhibitor NKT2152; HIF-2alpha Inhibitor NKT 2152;
NCIt definition : An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential
antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor NKT2152 targets
and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its
subsequent binding to DNA. This results in decreased transcription and expression
of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and
survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor
cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer
cell types, promotes proliferation, progression and metastasis of tumors.;
NCIt note : See 'Imdatifan(C203107)';
Concept status : Retired_Concept;
Molecule name : NKT 2152; NKT-2152;
NCI Metathesaurus CUI : CL1773733;
Origin ID : C185419;
UMLS CUI : C5666990;
Semantic type(s)
