Preferred Label : Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205;
NCIt synonyms : B7-H4 TOP1i ADC AZD8205; Anti-B7-H4/TOP1i ADC AZD8205; ADC AZD8205; Antibody-drug Conjugate AZD8205; Anti-B7-H4/Topoisomerase I Inhibitor ADC AZD8205;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked
to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity.
Upon administration, the anti-B7-H4 monoclonal antibody moiety of ADC AZD8205 targets
and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the
TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes.
This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA
repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing
B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a
variety of tumor cell types and tumor-associated macrophages. It negatively regulates
T-cell immune responses.;
Molecule name : AZD 8205; AZD-8205;
NCI Metathesaurus CUI : CL1773812;
Origin ID : C185401;
UMLS CUI : C5666984;
Semantic type(s)
- concept_is_in_subset
- has_target
