Preferred Label : SRC Family Oncogene;
NCIt definition : Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which
encode diverse SRC Family Tyrosine Kinases, closely related intracellular non-receptor
protein-tyrosine kinases with amino acid sequence similarity to SRC and to Rous sarcoma
virus oncogene protein PP60(V-SRC). SRC tyrosine kinases interact with diverse cell-surface
receptors and participate in intracellular signal transduction pathways in a variety
of hematopoietic cells. Oncogenic SRC kinases can occur through altered regulation
or expression of the endogenous protein and by virally encoded src (v-src) genes.
SRC family oncogenes disrupt normal cell function.;
Origin ID : C18540;
UMLS CUI : C0919476;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
