Pegfilgrastim - CISMeF

Preferred Label : Pegfilgrastim;

NCIt synonyms : Filgrastim SD-01; SD-01; SD-01 sustained duration G-CSF; Pegfilgrastim Biosimilar HSP-130; Pegfilgrastim Biosimilar Pegcyte; Pegfilgrastim Biosimilar Ziextenzo; Pegfilgrastim Biosimilar Udenyca; Pegfilgrastim Biosimilar Nyvepria; Pegfilgrastim Biosimilar PF-06881894; Pegylated G-CSF; Pegylated Granulocyte Colony Stimulating Factor; Pegylated GCSF;

NCIt related terms : filgrastim-SD/01; Neulasta; PEG-filgrastim; Pegfilgrastim-jmdb; Pegfilgrastim-bmez; Pegfilgrastim-apgf; Pegfilgrastim-cbqv;

NCIt definition : A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.;

UNII : 3A58010674;

CAS number : 208265-92-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 208265-92-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Neulasta; Neulastim; Fulphila; Jinyouli; Ziextenzo; Nyvepria; Pegcyte; Udenyca; Neupopeg;

Molecule name : HSP-130; PF-06881894;

Chemical formula : C3H8NO(C2H4O)n;

NSC code : 725961;

Codes from synonyms : CDR0000044860; CDR0000410749; CDR0000316080; 69847; 389; 93181; 390; 27416;

Details

Origin ID

C1854;

UMLS CUI

C1136535;

Automatic exact mappings (from CISMeF team)
- Pegfilgrastim [ICD-11 Extension code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pegfilgrastim (substance) [SNOMED CT concept]
- Product containing pegfilgrastim (medicinal product) [SNOMED CT concept]
- pegfilgrastim [ATC Code]
- pegfilgrastim [Substance BNPC]
- pegfilgrastim [International Nonproprietary Name]
- pegfilgrastim [MeSH Supplementary Concept]
- pegfilgrastim [MeSH concept]
Validated automatic mappings to BTNT
- pegfilgrastim [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Cell Differentiation [NCIt concept]
- Receptor Activation Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HL Authorized Value Terminology [NCIt concept]
- HL Concomitant Medication Table [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Fluorouracil/Paclitaxel/Pegfilgrastim [NCIt concept]
- Cyclophosphamide/Doxorubicin/Pegfilgrastim [NCIt concept]
- Docetaxel/Epirubicin/Pegfilgrastim [NCIt concept]
- Paclitaxel/Pegfilgrastim [NCIt concept]
- Pegfilgrastim Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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