Preferred Label : Doxorubicin Prodrug L-377,202;
NCIt synonyms : 5,12-Naphthacenedione, 10-((3-(((4R)-1-(4-carboxy-1-oxobutyl)-4-hydroxy-L-prolyl-L-alanyl-L-seryl-(2S)-2-cyclohexylglycyl-L-glutaminyl-L-seryl-L-leucyl)amino)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,
(8S,10S)-; L-377 202;
NCIt related terms : L-377202; L-377,202;
NCIt definition : A prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic
antibiotic doxorubicin. This complex is hydrolyzed by the enzyme prostate-specific
antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin.
Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing
PSA enzyme is localized to the prostate gland. Doxorubicin and leucine-doxorubicin
intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication
and repair and RNA and protein synthesis. These agents also produce toxic free-radical
intermediates and interact with cell membrane lipids causing lipid peroxidation.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer.;
UNII : VDXVABRQTV;
CAS number : 207395-85-5;
Molecule name : L-377202;
Codes from synonyms : CDR0000044855;
Origin ID : C1853;
UMLS CUI : C0879383;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
