Preferred Label : Kras G12C Inhibitor MK-1084;
NCIt definition : An orally available inhibitor of the oncogenic KRAS substitution mutation G12C, with
potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor MK-1084
selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated signaling.
This may halt proliferation and metastasis in susceptible tumor cells. KRAS, a member
of the RAS family of oncogenes, serves an important role in cell signaling, division
and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell proliferation, invasion, and metastasis.;
Molecule name : MK 1084; MK-1084;
NCI Metathesaurus CUI : CL1773394;
Origin ID : C185288;
UMLS CUI : C5666968;
Semantic type(s)
- concept_is_in_subset
- has_target
