Preferred Label : Lyophilized Inactivated Group A Streptococcus TARA-002;
NCIt definition : A lyophilized formulation containing cultures of the low-virulent Su strain of group
A Streptococcus pyogenes, treated and killed with penicillin G, with potential immunostimulating
and antineoplastic activities. Upon intravesical administration, lyophilized inactivated
group A Streptococcus TARA-002 may, as an immunostimulant, activate both the innate
and adaptive immune system. This enhances neutrophils, monocytes and lymphocyte tumor
infiltration and increases the production of key immune mediators, including interleukins
IL-6, IL-8, IL-12, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha, and
vascular endothelial growth factor (VEGF), thereby inducing antitumor immune responses.
TARA-002 is based on the same master cell bank of genetically distinct group A Streptococcus
pyogenes as OK-432.;
Molecule name : TARA 002; TARA-002;
NCI Metathesaurus CUI : CL1773391;
Origin ID : C185283;
UMLS CUI : C5666963;
Semantic type(s)
- concept_is_in_subset
