Intrathecal Deferoxamine

Preferred Label : Intrathecal Deferoxamine;

NCIt synonyms : IT Deferoxamine; IT Desferrioxamine; IT-DFO;

NCIt definition : An intrathecal (IT) formulation of deferoxamine (DFO), an iron-chelating agent that can be used to deplete free iron and lower iron levels, and with potential antineoplastic activity. Upon IT administration via Ommaya reservoir, DFO chelates free iron within the cerebrospinal fluid (CSF) by forming the iron complex ferrioxamine. This lowers the amount of iron available for cancer cell growth and survival. Cancer cells show increased iron uptake as iron is needed for rapid tumor cell proliferation.;

NCI Metathesaurus CUI : CL1773375;

Details

Origin ID

C185281;

UMLS CUI

C5666800;

Automatic exact mappings (from CISMeF team)
- Deferoxamine [LOINC Challenge]
- Deferoxamine [ICD-11 Extension code]
- Deferoxamine [ICHI extension code]
- Deferoxamine (substance) [SNOMED CT concept]
- deferoxamine [MeSH Descriptor]
- deferoxamine [ATC Code]
- deferoxamine [MeSH concept]
- deferoxamine [SNOMED Notion]
- deferoxamine [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Iron [NCIt concept]

Keyword's position in hierarchy(ies) :

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