Preferred Label : Cancer-Predisposing Gene;
NCIt synonyms : Cancer Susceptibility Gene; Susceptibility Gene;
NCIt related terms : predisposing mutation;
NCIt definition : Mutated forms of genes which encode proteins that are essential for the control and
maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type
form of these genes alters control of their expression, resulting in a change in control
of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer
somatic mutations for transformation of a particular cell, thereby predisposing them
to the development of cancer.;
Alternative definition : NCI-GLOSS: A germline mutation that increases an individual's susceptibility or predisposition
to a certain disease or disorder. When such a mutation is inherited, development of
symptoms is more likely, but not certain.;
Codes from synonyms : CDR0000460209; CDR0000460208;
Origin ID : C18521;
UMLS CUI : C0919453;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
