Preferred Label : GM-CSF-secreting MVX-2-loaded Capsules/Autologous Irradiated Tumor Cell Vaccine MVX-ONCO-2;
NCIt synonyms : Genetically-modified Cell-line Secreting GM-CSF Capsules and Irradiated Autologous
Tumor Cells MVX-ONCO-2;
NCIt definition : A cancer vaccine composed of autologous irradiated tumor cells and two implantable
capsules loaded with MVX-2 cells, which contain allogeneic genetically modified cells
that continuously release granulocyte-macrophage colony stimulating factor (GM-CSF),
with potential immunostimulating and antineoplastic activities. Upon administration
of GM-CSF-secreting MVX-2-loaded capsules/autologous irradiated tumor cell vaccine
MVX-ONCO-2, the MVX-2-loaded capsules and the autologous irradiated cells isolated
from the patient's own tumor are co-localized in the patient's tissue. GM-CSF is released,
and the immune system is exposed to the tumor-associated antigens (TAAs) expressed
by the autologous irradiated tumor cells at the injection site. GM-CSF recruits and
activates antigen-presenting cells (APC), which induces both antibody-dependent cell-mediated
cytotoxicity (ADCC) and cytotoxic T-lymphocyte (CTL) responses locally and systemically.
This may lead to tumor regression. By using the patient's own irradiated cancer cells
as vaccine antigens, the patient's immune system is exposed to the entire repertoire
of this individual's TAAs. The encapsulation of MVX-2 cells protects them from the
immune responses, thereby ensuring the continuous release of GM-CSF. GM-CSF, a monomeric
glycoprotein that functions as a cytokine, is a strong immune booster and plays an
important role in the activation of immune system.;
Molecule name : MVX-ONCO2; MVX-ONCO 2;
NCI Metathesaurus CUI : CL1773504;
Origin ID : C185159;
UMLS CUI : C5666952;
Semantic type(s)
- concept_is_in_subset
