Preferred Label : Actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A;
NCIt synonyms : 225Ac-DOTA-anti-CEA Monoclonal Antibody M5A; 225Ac-DOTA-M5A Humanized Anti-CEA Antibody;
NCIt definition : A radioimmunoconjugate comprised of M5A, a humanized monoclonal antibody directed
against carcinoembryonic antigen-related cell adhesion molecule 5 (CEA or CEACAM5),
conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with
potential antineoplastic activity. Upon administration, the monoclonal antibody moiety
of actinium Ac 225-DOTA-anti-CEA monoclonal antibody M5A specifically targets and
binds to CEA, thereby delivering a cytotoxic dose of alpha radiation to CEA-expressing
tumor cells. CEA, a tumor-associated antigen (TAA) and a member of the CEA family
of proteins, plays a key role in cell migration, cell invasion and cell adhesion,
and is overexpressed by a variety of cancer types.;
NCI Metathesaurus CUI : CL1773477;
Origin ID : C185145;
UMLS CUI : C5669722;
Semantic type(s)
- concept_is_in_subset
- has_target
