Preferred Label : DNA Plasmid Encoding Human IL-12 phIL12;
NCIt synonyms : hIL-12-encoding DNA Plasmid phIL12; DNA Plasmid Encoding hIL-12 phIL12; IL-12 DNA Plasmid phIL12;
NCIt definition : A preparation of non-viral DNA plasmids encoding the human pro-inflammatory cytokine
interleukin-12 (IL-12), constructed with a p21 promoter and devoid of an antibiotic
resistance gene, with potential immunostimulating and antineoplastic activities. Upon
administration of DNA plasmid encoding human IL-12 (hIL-12) phIL12 via intratumoral
injection and electroporation, or gene electrotransfer (GET), the plasmid is introduced
into human cells resulting in the expression and highly-localized secretion of IL-12
in the tumor microenvironment (TME). This activates the immune system by promoting
the activation of natural killer cells (NKs), inducing the secretion of interferon-gamma
(IFN-g) and promoting cytotoxic T-lymphocyte (CTL) responses against tumor cells.
The switch from the constitutive promoter to the tumor-specific and genotoxic stress-inducible
p21 promoter in the construction of phIL12 allows for high basal IL-12 expression
in tumor cells. The lack of an antibiotic resistance gene improves the safety profile.;
Molecule name : phIL-12; p21-hIL-12-ORT; phIL 12;
NCI Metathesaurus CUI : CL1773463;
Origin ID : C185130;
UMLS CUI : C5666947;
Semantic type(s)
- concept_is_in_subset
