Preferred Label : Antibody STING Drug Conjugate TAK-500;
NCIt synonyms : ADC STING Agonist TAK-500; Stimulator of Interferon Genes Agonist TAK-500; ADC TAK-500; STING ADC TAK-500; Antibody-drug Conjugate TAK-500;
NCIt definition : An antibody-drug conjugate (ADC) composed of an as of yet undisclosed antibody conjugated
to TAK-676, an agonist for the stimulator of interferon genes (STING; transmembrane
protein 173; TMEM173), with potential immuno-activating and antineoplastic activities.
Upon intravenous administration, antibody STING drug conjugate TAK-500 targets and
binds to the undisclosed target, thereby allowing TAK-676 to bind to STING. This activates
the STING pathway in immune cells in the tumor microenvironment (TME). This leads
to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances
the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs),
and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer
cells. STING, a transmembrane protein that activates immune cells in the TME, plays
a key role in the activation of the innate immune system. The conjugation of the antibody
to TAK-676 improves targeted delivery of the STNG agonist and increases tumor exposure
to TAK-676 and enhances the STING-mediated anti-tumor immune responses.;
Molecule name : TAK-500; TAK 500;
NCI Metathesaurus CUI : CL1773460;
Origin ID : C185129;
UMLS CUI : C5666946;
Semantic type(s)
- concept_is_in_subset
