" /> Ibentatug - CISMeF





Preferred Label : Ibentatug;

NCIt synonyms : Anti-plectin-1 Monoclonal Antibody ZB131; Anti-CSP1 Monoclonal Antibody ZB131; Anti-cell Surface Plectin-1 Monoclonal Antibody ZB131; Anti-cell Surface Plectin 1 Monoclonal Antibody ZB131; Anti-cancer-specific Plectin Monoclonal Antibody ZB131; Anti-CSP Monoclonal Antibody ZB131; Anti-plectin Monoclonal Antibody ZB131;

NCIt definition : A humanized monoclonal antibody directed against human plectin (plectin-1; plectin 1), with potential antineoplastic activity. Upon administration, ibentatug specifically binds to plectin expressed on the cell surface of cancer cells, thereby activating the immune system to induce an anti-tumor T-cell response against plectin-expressing cancer cells and inducing apoptosis in these cancer cells. Plectin, a pro-tumorigenic protein, is normally found inside the cytoplasm of healthy cells but is only selectively expressed on the cell surface of various cancer cells. Cancer-specific plectin (CSP), also known as cell surface plectin-1 (CSP1), plays an important role in cancer cell proliferation, migration and invasion.;

UNII : MGW2V5VJ5J;

CAS number : 2767983-94-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2767983-94-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ZB 131; ZB-131;

NCI Metathesaurus CUI : CL1773474;

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12/05/2024


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