Preferred Label : Oncolytic Adenovirus Expressing Interferon Beta/CD40 Ligand MEM-288;
NCIt synonyms : Interferon Beta/Chimeric CD40 Ligand-encoding Adenovirus Vector MEM-288; Oncolytic Adenovirus Expressing IFN-beta/CD40L MEM-288; Oncolytic Adenovirus Expressing IFN-beta/MEM40 MEM-288; Oncolytic Adenovirus Expressing Human Interferon Beta and Recombinant CD40 Ligand
MEM-288; IFN-beta and Chimeric CD40 Ligand-encoding Adenovirus Vector MEM-288;
NCIt definition : A conditionally replicative, oncolytic adenovirus that has been genetically engineered
to encode the transgenes for the human cytokine interferon beta (IFN-beta) and MEM40,
a recombinant, chimeric form of CD40 ligand (CD40L), with potential immunostimulating
and antineoplastic activities. Upon intratumoral administration, the oncolytic adenovirus
expressing IFN-beta/CD40L MEM-288 selectively infects and replicates in tumor cells,
leading to tumor cell lysis. In addition, the IFN-beta expressed by the oncolytic
adenovirus activates T-lymphocytes, dendritic cells (DCs) and natural killer (NK)
cells and induces an anti-tumor immune response against the tumor cells. The CD40L
expressed by the oncolytic adenovirus specifically binds to and activates CD40, a
cell surface receptor that belongs to the tumor necrosis factor (TNF) receptor family
and is expressed on various immune cells, such as B-lymphocytes, monocytes, and DCs.
Activation of CD40 induces proliferation and activation of B-lymphocytes, shifts the
induction of immunosuppressive macrophages towards immunostimulatory macrophages,
activates monocyte-derived DCs (moDCs) and leads to the secretion of inflammatory
cytokines. This activates the immune system to mount a cytotoxic T-lymphocyte (CTL)
immune response against tumor cells.;
Molecule name : MEM-288; MEM 288;
NCI Metathesaurus CUI : CL1773469;
Origin ID : C185120;
UMLS CUI : C5666937;
Semantic type(s)
- concept_is_in_subset
