Preferred Label : BCL1 Oncogene;
Obsolete resource : true;
NCIt synonyms : B-cell Leukemia 1; B-Cell Chronic Lymphocytic Leukemia Associated Oncogene; BCL;
NCIt definition : Human cyclin D1 (BCL1) proto-oncogene, located at 11q13, encodes G1/S-specific cyclin
D1 (CCND1) protein. BCL1 gene expression is activated in human B-cell lymphomas by
translocation, t(11;14)(q13;q32), with immunoglobulin gene regions. Enhanced expression
of cyclin D1 protein has also been detected in parathyroid adenomas due to a translocation,
t(11;11)(q13;p15), resulting in fusion of BCL1 with the parathyroid hormone enhancer.;
Concept status : Retired_Concept;
Origin ID : C18512;
OMIM relation
- Semantic type(s)
