" /> Collagen Alpha-1(VIII) Chain - CISMeF





Preferred Label : Collagen Alpha-1(VIII) Chain;

NCIt synonyms : Endothelial Collagen; Collagen Type VIII Alpha 1 Chain; COL8A1;

NCIt definition : Collagen alpha-1(VIII) chain (744 aa, 73 kDa) is encoded by the human COL8A1 gene. This protein plays a role in the structure of Descemet's membrane and blood vessel endothelium.;

NCIt note : Collagen alpha-1(VIII) chain can be cleaved by neutrophil elastase to yield the C-terminal NC1 domain fragment, vastatin. The NC1 fragment inhibits aortic endothelial cell proliferation and promotes apoptosis. (UniProt); Collagen alpha-1(VIII) chain can form homotrimeric fibrils or heterotrimers in association with collagen alpha-2(VIII) chains. (UniProt);

NCI Metathesaurus CUI : CL791815;

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31/07/2025


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