Collagen Alpha-1(VIII) Chain

Preferred Label : Collagen Alpha-1(VIII) Chain;

NCIt synonyms : Endothelial Collagen; Collagen Type VIII Alpha 1 Chain; COL8A1;

NCIt definition : Collagen alpha-1(VIII) chain (744 aa, 73 kDa) is encoded by the human COL8A1 gene. This protein plays a role in the structure of Descemet's membrane and blood vessel endothelium.;

NCIt note : Collagen alpha-1(VIII) chain can be cleaved by neutrophil elastase to yield the C-terminal NC1 domain fragment, vastatin. The NC1 fragment inhibits aortic endothelial cell proliferation and promotes apoptosis. (UniProt); Collagen alpha-1(VIII) chain can form homotrimeric fibrils or heterotrimers in association with collagen alpha-2(VIII) chains. (UniProt);

NCI Metathesaurus CUI : CL791815;

Details

Origin ID

C185040;

UMLS CUI

C4549754;

Automatic exact mappings (from CISMeF team)
- Collagen, type VIII, alpha-1 [OMIM gene]
- collagen type VIII alpha 1 chain [HGNC gene]
OMIM relation
- Collagen, type VIII, alpha-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Col8A1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- COL8A1 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Blood Vessel Endothelium [NCIt concept]
- Descemet's Membrane [NCIt concept]
gene_product_has_associated_anatomy
- Basement Membrane [NCIt concept]
- Extracellular Matrix [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Eye Development [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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