Preferred Label : Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV;
NCIt synonyms : SQZ-AAC-HPV; HPV aAPC RTX-321AACs Generated from RBCs Engineered with HPV16 Epitopes; Engineered AAC Loaded with HPV16 Epitopes; Squeezed Red Blood Cells Activating Antigen Carriers-HPV16; Activating Antigen Carriers Engineered from Squeezed RBCs with HPV16 Epitopes; SQZ AACs-expressing HPV16 Epitopes;
NCIt definition : A cell therapy agent composed of autologous red blood cells (RBCs) engineered to act
as artificial antigen carriers (AACs) and expressing tumor-specific antigens (TAAs),
human papillomavirus (HPV) type 16 epitopes, and containing a Toll-like receptor (TLR)
agonist as an activating adjuvant, with potential immunomodulating and antineoplastic
activities. Using cell squeeze technology, the RBCs are squeezed (SQZ) and loaded
with TAAs and an adjuvant to generate SQZ AACs that appear similar to aged RBCs. Upon
administration of the SQZ RBCs expressing HPV16 epitopes SQZ-AAC-HPV, the SQZ RBCs
are rapidly taken up by the patient's professional antigen-presenting cells (APCs)
similar to the process of natural clearance and destruction of aged RBCs. In turn,
the HPV16 epitopes are presented to the immune system and activate the immune system
to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing
HPV16. By mimicking natural aged RBCs, the AACs are able to activate an anti-tumor
immune response against the TAA-expressing tumor cells. HPV16 plays an important role
in the development of certain types of cancer.;
NCI Metathesaurus CUI : CL1772922;
Origin ID : C184978;
UMLS CUI : C5666822;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
