Preferred Label : pH-Low Insertion Peptide-Indocyanine Green;
NCIt synonyms : pHLIP (R)-ICG; pH-Low Insertion Peptide-ICG; ICG pHLIP (R);
NCIt definition : An imaging agent composed of a pH-low insertion peptide (pHLIP) probe coupled with
the near infrared (NIR) fluorescent dye indocyanine green (ICG), that may be used
for cancer imaging using NIR imaging. Upon administration of pHLIP-ICG during surgery,
the pHLIP moiety specifically targets and gets inserted into the cellular membrane
of tumor cells as the tumor cell environments are more acidic than normal, healthy
tissue environments. More specifically, the pHLIP forms an alpha helix and becomes
inserted across the cell membrane specifically at the low extracellular pH found within
tumors whereas they are unfolded and unbound at higher pHs. Upon NIR imaging, tumor
cells and the extent of acidity can be visualized and assessed, marking the tumor
cells for surgical removal.;
NCI Metathesaurus CUI : CL1772896;
Origin ID : C184944;
UMLS CUI : C5669668;
Semantic type(s)
- concept_is_in_subset
