Preferred Label : Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells;
NCIt synonyms : Donor-derived Haploidentical IL-21-Expanded NKs; IL-21-treated HLA-haploidentical Donor NK Cells; Donor-derived IL-21 Expanded NK Cells; Allogeneic IL-21-expanded haploNKs;
NCIt definition : A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human
leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential
immunomodulating and antineoplastic activities. Upon administration in patients undergoing
HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical
IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained
ex vivo proliferation of human NK cells and enhances its cytotoxic activity.;
NCI Metathesaurus CUI : CL1773005;
Origin ID : C184812;
UMLS CUI : C5669551;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
