Preferred Label : RNase-Fc Fusion Protein RSLV-132;
NCIt related terms : RSLV-132;
NCIt definition : A fusion protein composed of a full-length, catalytically active human ribonuclease
(RNase) moiety fused to the amino-terminus of an engineered human immunoglobulin G1
(IgG1) Fc domain, with potential anti-inflammatory and immunomodulatory activities.
Upon administration, RNase-Fc fusion protein RSLV-132 catalyzes the degradation of
extracellular RNA circulating in the blood and removes them from the blood circulation.
This may prevent the presentation of RNA autoantigens to the immune system and reduce
inflammation. Circulating RNA-containing autoantigens and autoantibodies drive chronic
inflammation in autoimmune diseases such as lupus and Sjogren's syndrome. Both viral
RNA and RNA-containing autoantibodies in the blood circulation may be associated with
inflammation in post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID.;
UNII : 6RQ92PNH8Z;
Molecule name : RSLV 132; RSLV-132;
NCI Metathesaurus CUI : CL1773106;
Origin ID : C184789;
UMLS CUI : C4705323;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
