Preferred Label : Bacterial Type III Secretion-based Agent T3P-Y058-739;
NCIt synonyms : Bacterial T3S-based Agent T3P-Y058-739; Yersinia enterocolitica T3S-based Protein Delivery Agent T3P-Y058-739; Bacterial Type III Secretion-based Protein Delivery Agent T3P-Y058-739; Yersinia enterocolitica-based Therapeutic T3P-Y058-739;
NCIt definition : A therapeutic based on a genetically-modified, live attenuated strain of the bacterium
Yersinia enterocolitica that is able to deliver a combination of as of yet undisclosed
type I interferons (IFN) and toll-like receptor (TLR) protein payloads, with potential
immunomodulating and antineoplastic activities. Upon administration, bacterial type
III secretion (T3S)-based agent T3P-Y058-739 may selectively target tumor cells, colonize
and deliver the protein payloads into tumor cells. This may activate type I IFN- and
TLR-mediated signaling, thereby activating an immune response and killing tumor cells.;
Molecule name : T3P-Y058 739; T3P-Y058739;
NCI Metathesaurus CUI : CL1773063;
Origin ID : C184738;
UMLS CUI : C5666932;
Semantic type(s)
- concept_is_in_subset
