Preferred Label : IRDye800CW-labeled GPC3-targeted Agent;
NCIt synonyms : Anti-GPC3-IRDye800CW; Anti-glypican-3-IRDye800CW;
NCIt definition : A fluorescence imaging agent and an immunoconjugate comprised of a GPC3-targeting
moiety conjugated to the near-infrared (NIR) fluorescent dye IRDye800CW, that can
potentially be used for the imaging of GPC3-expressing tumor cells. Upon administration
of the IRDye800CW-labeled GPC3-targeted agent, the GPC3-targeting moiety targets and
binds to GPC3 expressed on tumor cells. Upon fluorescence imaging of the fluorophore
IRDye800CW, the GPC3-expressing tumor cells can be visualized and detected. GPC3,
a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed
on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3
plays an important role in cellular proliferation and differentiation.;
NCI Metathesaurus CUI : CL1773064;
Origin ID : C184735;
UMLS CUI : C5669497;
Semantic type(s)
- concept_is_in_subset
- has_target
