Oncogene HST - CISMeF

Preferred Label : Oncogene HST;

NCIt synonyms : Human Stomach Cancer Derived Oncogene; HSTF1; FGF4 Oncogene; K-FGF; Kaposi Sarcoma Oncogene; FGF4; Fibroblast Growth Factor 4 Oncogene;

NCIt definition : Human Oncogene HST is a mutated variant of FGF4 Gene (FGF Family) about 35 kb downstream of INT2 (same orientation), which encodes Fibroblast Growth Factor 4, a heparin-binding growth factor with homology to basic and acidic FGF. Gremlin relays an SHH signal from the polarizing region to the apical ectodermal ridge. Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop. Oncogene HST disrupts normal cell function.;

NCI Metathesaurus CUI : CL448415;

GenBank Accession Number : J02986;

Details

Origin ID

C18462;

UMLS CUI

C0919466;

Currated CISMeF NLP mapping
- Fibroblast growth factor 4 [OMIM gene]
- fibroblast growth factor 4 [HGNC gene]
OMIM relation
- Fibroblast growth factor 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Fibroblast growth factor 4 [OMIM gene]
- fibroblast growth factor 4 [HGNC gene]
allele_in_chromosomal_location
- 11q13.3 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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