Oncogene TRK - CISMeF

Preferred Label : Oncogene TRK;

NCIt synonyms : Oncogene, NTRK1; Oncogene, Neurotrophic Tyrosine Kinase, Receptor, Type 1 Gene; Oncogene, TRKA;

NCIt definition : Human Oncogene TRK is a mutated variant of NTRK1 Gene (INSR family), which encodes two alternative type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1 with similar biological properties. TRKA-II is primarily expressed in neurons; TRKA-I is non-neuronal. NTRK1 exists as low affinity monomeric and high affinity dimeric structures, with TRKA, TRKB, or TRKC, that bind neurotrophins. TRKA, TRKB, and TRKC partners are preferred by NGF, NTF5 and BDNF, and NTF3, respectively. Ligands stimulate autophosphorylation of TRK. NTRK1 defects cause CIPA. Oncogene TRK disrupts normal cell function.;

NCI Metathesaurus CUI : CL512814;

Details

Origin ID

C18457;

UMLS CUI

C5574901;

False automatic mappings
- Neurotrophic tyrosine kinase, receptor, type 1 [OMIM gene]
- Tropomyosin 3 [OMIM gene]
OMIM relation
- Neurotrophic tyrosine kinase, receptor, type 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
allele_in_chromosomal_location
- 1q21-q22 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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