NCIt definition : A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene
glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity
of this agent is derived from its interferon alpha-2b protein moiety. Interferons
alfa bind to specific cell-surface receptors, leading to the transcription and translation
of genes whose protein products mediate antiviral, antiproliferative, anticancer,
and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b,
thereby extending the duration of its therapeutic effects, but may also reduce the
interferon-mediated stimulation of an immune response. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat hepatitis C infections. It is also being studied in
the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory.
It is a type of biological response modifier.;
UNII : G8RGG88B68;
CAS number : 215647-85-1;
Drug name : PEG-Intron; Sylatron; PEG Intron;
Molecule name : SCH-54031;
Chemical formula : C2H4NO2(C2H4O)n;
NSC code : 720033;
ChEBI ID : CHEBI:63615;
Codes from synonyms : CDR0000046746; CDR0000410755; CDR0000046202; 392;