Oncogene LMYC - CISMeF

Preferred Label : Oncogene LMYC;

NCIt synonyms : MYC Related Gene From Lung Cancer;

NCIt definition : Human Oncogene LMYC is a mutated variant of LMYC Gene (MYC Family), which encodes L-MYC Protein, a bZIP transcription factor that binds to DNA as a heterodimer with MAX; DNA binding requires dimerization with another bHLH protein. The gene is amplified 10- to 20-fold in small-cell lung cancer (SCCL). Several LMYC mRNAs are produced in SCCL cells by alternative splicing and alternative polyadenylation. Oncogene LMYC disrupts normal cell function.;

NCI Metathesaurus CUI : CL448412;

GenBank Accession Number : M19720;

Details

Origin ID

C18443;

UMLS CUI

C0812289;

Currated CISMeF NLP mapping
- MYCL proto-oncogene, bHLH transcription factor [HGNC gene]
- Mycl protooncogene, bhlh transcription factor [OMIM gene]
OMIM relation
- Mycl protooncogene, bhlh transcription factor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- MYCL proto-oncogene, bHLH transcription factor [HGNC gene]
- Mycl protooncogene, bhlh transcription factor [OMIM gene]
allele_in_chromosomal_location
- 1p34.3 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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