Preferred Label : TRK Inhibitor TQB3811;
NCIt definition : An orally bioavailable inhibitor of tropomyosin receptor kinase (TRK), with potential
antineoplastic activity. Upon oral administration, TRK inhibitor TQB3811 targets and
binds to TRK, thereby preventing neurotrophin-TRK interaction and TRK activation.
This may lead to apoptosis of TRK-expressing tumor cells and the inhibition of tumor
cell proliferation in TRK-expressing tumors. Members of TRK, a family of receptor
tyrosine kinases activated by neurotrophins, are mutated in a variety of cancer cell
types and play an important role in tumor cell growth and survival.;
Molecule name : TQB 3811; TQB-3811;
NCI Metathesaurus CUI : CL1772568;
Origin ID : C184381;
UMLS CUI : C5666928;
Semantic type(s)
- concept_is_in_subset
