Preferred Label : CDC7 Inhibitor TQB3824;
NCIt synonyms : Cell Division Cycle 7 Kinase Inhibitor TQB3824; CDC7 Kinase Inhibitor TQB3824;
NCIt definition : An orally bioavailable inhibitor of cell division cycle 7 (CDC7) kinase, with potential
antineoplastic activity. Upon oral administration, CDC7 inhibitor TQB3824 targets,
binds to and inhibits the activity of CDC7, which may result in the inhibition of
DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition
of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine
kinase overexpressed in a variety of tumor cell types, plays a key role in DNA replication
and DNA damage response by binding to and phosphorylating serine (Ser)-40 and 53 of
minichromosome maintenance complex component 2 (MCM2).;
Molecule name : TQB-3824; TQB 3824;
NCI Metathesaurus CUI : CL1772563;
Origin ID : C184374;
UMLS CUI : C5666922;
Semantic type(s)
- concept_is_in_subset
- has_target
