Preferred Label : Salmonella enterica Serotype Typhimurium Expressing L-methioninase SGN1;
NCIt related terms : SGN-1;
NCIt definition : A genetically modified strain of Salmonella enterica, serotype typhimurium that expresses
L-methioninase, with potential antineoplastic activity. Upon administration, Salmonella
enterica serotype typhimurium expressing L-methioninase SGN1 selectively accumulates
and replicates in tumor cells, inhibiting the growth of tumors. SGN1 also delivers
the oncolytic enzyme L-methioninase, a pyridoxal phosphate-dependent enzyme that catalyzes
the elimination of L-methionine, to tumor cells. This eliminates L-methionine and
results in cell-cycle arrest at the S/G2 phase and tumor cell death. Most tumors are
methionine-dependent for growth and proliferation.;
UNII : 6CCT5H8PTZ;
Drug name : SalMet-Vec;
Molecule name : SGN-1; SGN 1;
NCI Metathesaurus CUI : CL1772548;
Origin ID : C184371;
UMLS CUI : C5575603;
Semantic type(s)
- concept_is_in_subset
- has_target
