NCIt definition : A bispecific monoclonal antibody targeting CD3, a T-cell surface antigen, and CD38,
a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential
antineoplastic activity. Upon administration, anti-CD3/CD38 bispecific monoclonal
antibody XmAb18968 binds to both CD3 on T-cells and CD38 expressed on tumor cells.
The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response
against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is
present on various immune cells and hematologic malignancies; its expression has been
correlated with poor prognosis.;
Semantic type(s)