Anti-CD38/CD3 Bispecific Monoclonal Antibody XmAb18968

Preferred Label : Anti-CD38/CD3 Bispecific Monoclonal Antibody XmAb18968;

NCIt synonyms : Anti-CD3/CD38 Bispecific Monoclonal Antibody XmAb18968; CD3 x CD38 Bispecific Monoclonal Antibody XmAb18968;

NCIt definition : A bispecific monoclonal antibody targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD3/CD38 bispecific monoclonal antibody XmAb18968 binds to both CD3 on T-cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.;

Molecule name : XmAb 18968; XmAb-18968;

NCI Metathesaurus CUI : CL1772550;

Détails

Origin ID

C184369;

UMLS CUI

C5666920;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]

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