Preferred Label : Anti-BCMA CAR-NK Cells;
NCIt synonyms : Anti-BCMA CAR-Natural Killer Cells; Anti-BCMA CAR-NKs;
NCIt definition : A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) expressing
a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA)
B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member
17; TNFRSF17), with potential immunomodulating and antineoplastic activities. Upon
transfusion, the anti-BCMA CAR-NK cells recognize, bind to and induce selective cytotoxicity
in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing
ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis
factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells,
is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation
and survival.;
NCI Metathesaurus CUI : CL1772621;
Origin ID : C184309;
UMLS CUI : C5669194;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
