Preferred Label : BMS-184476;
NCIt synonyms : 7-O-[(Methylthio)methyl]paclitaxel; beta-(Benzoylamino)-a-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H;
NCIt related terms : beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H;
NCIt definition : A 7-methylthiomethyl ether derivative of paclitaxel with antineoplastic activity.
BMS-184476 binds to and stabilizes the resulting microtubules, thereby inhibiting
microtubule disassembly which results in cell- cycle arrest at the G2/M phase and
apoptosis. (NCI);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called mitotic inhibitors.;
UNII : 3811W2NBZ8;
CAS number : 160237-25-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 160237-25-2
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G-SRS /a ;
Molecule name : BMS-184476;
Codes from synonyms : 50582; CDR0000046176;
Origin ID : C1843;
UMLS CUI : C0796479;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
