Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123

Preferred Label : Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123;

NCIt synonyms : L-778 123;

NCIt related terms : L-778123; 4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile Monohydrochloride; L-778,123;

NCIt definition : A benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells.;

UNII : 2A2059P49U;

CAS number : 253863-00-2;

Molecule name : L-778123; L 778123;

Codes from synonyms : CDR0000046094; 50599;

Details

Origin ID

C1840;

UMLS CUI

C0796327;

Automatic exact mappings (from CISMeF team)
- L 778,123 [MeSH concept]
- L 778,123 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- L 778,123 [MeSH Supplementary Concept]
- L 778,123 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- L-778,123/Paclitaxel [NCIt concept]

Keyword's position in hierarchy(ies) :

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