Lepirudin - CISMeF

Preferred Label : Lepirudin;

NCIt synonyms : Recombinant Hirudin;

NCIt definition : A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.;

Alternative definition : NCI-GLOSS: A drug that inhibits blood clotting. It is being studied in cancer treatment.;

UNII : Y43GF64R34;

CAS number : 138068-37-8;

Drug name : Refludan;

Chemical formula : C287H440N80O111S6;

Codes from synonyms : CDR0000046191; 302;

Details

Origin ID

C1839;

UMLS CUI

C0772394;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lepirudin [LOINC component]
- Lepirudin (substance) [SNOMED CT concept]
- Product containing lepirudin (medicinal product) [SNOMED CT concept]
- lepirudin [ATC Code]
- lepirudin [International Nonproprietary Name]
- lepirudin [MeSH Supplementary Concept]
- lepirudin [MeSH concept]
Validated automatic mappings to BTNT
- lepirudin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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