Preferred Label : Allogeneic Anti-CD33 CAR NK Cells;
NCIt synonyms : Allogeneic Anti-CD33 Chimeric Antigen Receptor-Natural Killer Cells;
NCIt definition : A preparation of off-the-shelf natural killer (NK) cells engineered to express a chimeric
antigen receptor (CAR) specific for the cluster of differentiation 33 (CD33) antigen,
with potential immunostimulating and antineoplastic activities. Upon administration,
the allogeneic anti-CD33 CAR NK cells target and bind to CD33 expressed on the surface
of tumor cells. This induces selective toxicity in tumor cells expressing CD33. CD33
is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia
cells.;
NCI Metathesaurus CUI : CL1771887;
Origin ID : C183523;
UMLS CUI : C5668443;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
