Preferred Label : Oncogenes, Tyrosine-Kinase;
NCIt synonyms : Tyrosine-Kinase Oncogene;
NCIt definition : Activated forms of tyrosine kinase family proto-oncogenes that contribute to the development
of cancer. These proto-oncogenes encode tyrosine kinase proteins, which are enzymes
that play a major role in mitogenic signaling by catalyzing the phosphorylation of
tyrosine residues in proteins. Tyrosine kinase oncogenes exhibit aberrant gene expression,
resulting in elevated levels of their protein products which disrupts mitotic checkpoints.;
Origin ID : C18344;
UMLS CUI : C0812221;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
