Preferred Label : Oncogenes, Growth Factor;
NCIt synonyms : Growth Factor Oncogene;
NCIt definition : Mutated forms of growth factor genes which encode a diverse group of extracellular
regulatory growth factor signaling molecules. These protein products play roles in
the division, growth, proliferation, survival and differentiation of cells. Under
normal cellular conditions, the activity of these proteins is tightly controlled.
Activation of growth factor proto-oncogenes via mutation results in growth factor
oncogenes. These aberrant genes express protein products that disrupt normal cell
function.;
Origin ID : C18341;
UMLS CUI : C0812218;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
