Oncogene ROS - CISMeF

Preferred Label : Oncogene ROS;

NCIt synonyms : Avian UR2 Sarcoma Virus Oncogene Homolog 1;

NCIt definition : Highly-expressed in a variety of tumor cell lines, human Oncogene ROS is a mutated variant of ROS1 Gene, which belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The encoded type I integral membrane protein, Tyrosine-Protein Kinase ROS, with tyrosine kinase activity may function as a growth or differentiation factor receptor. Oncogene ROS1 disrupts normal cell function.;

NCI Metathesaurus CUI : CL1642989;

GenBank Accession Number : M34353;

Details

Origin ID

C18339;

UMLS CUI

C0812281;

Automatic exact mappings (from CISMeF team)
- Ros protooncogene 1, receptor tyrosine kinase [OMIM gene]
OMIM relation
- Ros protooncogene 1, receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- ROS proto-oncogene 1 [LOINC component]
- ROS proto-oncogene 1, receptor tyrosine kinase [HGNC gene]
- Ros protooncogene 1, receptor tyrosine kinase [OMIM gene]
allele_in_chromosomal_location
- 6q22 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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