Oncogene LCK - CISMeF

Preferred Label : Oncogene LCK;

NCIt definition : Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation; p56LCK regulates allelic exclusion at the TCR beta locus. It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. Oncogene LCK disrupts normal cell function.;

NCI Metathesaurus CUI : CL448408;

GenBank Accession Number : M36881;

Details

Origin ID

C18334;

UMLS CUI

C0919477;

Currated CISMeF NLP mapping
- LCK proto-oncogene, Src family tyrosine kinase [HGNC gene]
- Lck protooncogene, src family tyrosine kinase [OMIM gene]
OMIM relation
- Lck protooncogene, src family tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- LCK proto-oncogene, Src family tyrosine kinase [HGNC gene]
- Lck protooncogene, src family tyrosine kinase [OMIM gene]
allele_in_chromosomal_location
- 1p35-p34.3 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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