Preferred Label : ChAdOx1-vectored COVID-19 Variant Vaccine AZD2816;
NCIt synonyms : B.1.351 Vaccine AZD2816; SARS-CoV-2 Vaccine AZD2816;
NCIt definition : A vaccine composed of a replication-deficient chimpanzee adenovirus, ChAdOx1, encoding
the spike (S) glycoprotein of the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) beta (B.1.351, South African) variant, with potential immunomodulating
and anti-viral activities. Upon administration, ChAdOx1-vectored COVID-19 variant
vaccine AZD2816 expresses the SARS-CoV-2 beta variant S protein, which contains ten
changes across the S protein. This induces a humoral and cell-mediated immune response
against SARS-CoV-2, and may prevent SARS-CoV-2 infection and inhibit viral replication.
S protein, usually found on the surface of SARS-CoV-2, plays an essential role in
the infection pathway of the SARS-CoV-2 virus. AZD2816 may induce neutralizing antibodies
against SARS-CoV-2 variants including beta, gamma (P.1) and delta (B.1.617.2).;
Molecule name : AZD 2816; AZD-2816;
NCI Metathesaurus CUI : CL1771597;
Origin ID : C183335;
UMLS CUI : C5666911;
Semantic type(s)
- concept_is_in_subset
