" /> Lufotrelvir - CISMeF





Preferred Label : Lufotrelvir;

NCIt definition : A phosphate prodrug of PF-00835231, a broad-spectrum inhibitor of coronavirus 3CL protease (3CLpro), with potential antiviral activity against coronaviruses including severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and SARS coronavirus-2 (SARS-CoV-2). Upon administration, lufotrelvir is converted to its active moiety, PF-00835231, which selectively targets and inhibits the activity of coronavirus 3CLpro. This inhibits the proteolytic cleavage of viral polyproteins and the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication.;

UNII : XJ51YOB1SC;

CAS number : 2468015-78-1;

Molecule name : WHO 12095; PF 07304814; PF-07304814;

NCI Metathesaurus CUI : CL1771581;

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Keyword's position in hierarchy(ies) : arborescence

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04/05/2025


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