" /> Lufotrelvir - CISMeF





Preferred Label : Lufotrelvir;

NCIt definition : A phosphate prodrug of PF-00835231, a broad-spectrum inhibitor of coronavirus 3CL protease (3CLpro), with potential antiviral activity against coronaviruses including severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and SARS coronavirus-2 (SARS-CoV-2). Upon administration, lufotrelvir is converted to its active moiety, PF-00835231, which selectively targets and inhibits the activity of coronavirus 3CLpro. This inhibits the proteolytic cleavage of viral polyproteins and the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication.;

UNII : XJ51YOB1SC;

CAS number : 2468015-78-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2468015-78-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : WHO 12095; PF 07304814; PF-07304814;

NCI Metathesaurus CUI : CL1771581;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
21/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.