Preferred Label : Pegipanermin;
NCIt synonyms : DN-TNF;
NCIt definition : A pegylated, human, engineered dominant-negative tumor necrosis factor (TNF; TNF-alpha)
variant devoid of TNF receptor-binding activity, with potential anti-inflammatory
activity. Upon administration, pegipanermin forms heterotrimers with native soluble
TNF (sTNF) but not membrane-bound transmembrane TNF (tmTNF). This prevents the binding
of sTNF with TNF receptors and inhibits sTNF pro-inflammatory signaling, thereby reducing
inflammation. TNF, a pro-inflammatory cytokine, is upregulated in various diseases
and in cytokine storm. sTNF signaling, primarily via TNF receptor 1 (TNFR1; CD120a;
p55/p60), may be responsible for exacerbation of existing inflammatory response while
tmTNF signaling, primarily via TNF receptor 2 (TNFR2; CD120b; p75/p80), plays an important
role in immune system development and cell survival.;
UNII : BM6T2K8FIN;
CAS number : 2489785-77-3;
Drug name : Quellor;
Molecule name : INB03; XPro1595; XENP345;
NCI Metathesaurus CUI : CL1771583;
Origin ID : C183319;
UMLS CUI : C5668305;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
